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Updated: May 23, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
Published on: July 20, 2016
Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides
Mathew W Jones1, Rachel A Strickland, Felix F Schumacher
1Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
Abstract:
The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.
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