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Related Experiment Video

Updated: May 23, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Reduced coagulation at high altitude identified by thromboelastography.

Daniel S Martin¹, Jim S Pate, Andre Vercueil

¹UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, UK. daniel.martin@ucl.ac.uk

Thrombosis and Haemostasis

|March 23, 2012

Summary

High altitude exposure slows blood clotting. Thromboelastography (TEG) revealed increased reaction and kinetic times, indicating delayed clot formation in healthy volunteers at 5,300 meters.

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Area of Science:

Physiology
Altitude Medicine
Hemostasis

Background:

The effects of hypoxemia on blood coagulation are not fully understood.
Previous studies have used various methods to assess coagulation at high altitudes with unclear results.

Purpose of the Study:

To investigate the impact of high altitude on blood coagulation dynamics.
To report the first use of thromboelastography (TEG) at high altitude to analyze clot formation.

Main Methods:

Seventeen healthy volunteers ascended to 5,300 meters.
Thromboelastography (TEG) measurements were taken at sea level, 4,250 m, and 5,300 m.
Peripheral oxygen saturation (SpO2) and hematocrit were also monitored.

Main Results:

SpO2 decreased significantly with altitude, while hematocrit increased.
TEG reaction time and kinetic time were prolonged at 5,300 m compared to sea level.
The alpha angle decreased, indicating slower clot kinetics, with no change in maximum clot strength.

Conclusions:

High altitude exposure leads to a pattern of slowed blood coagulation.
TEG is a valuable tool for assessing coagulation changes at extreme altitudes.
Further research is needed to understand the clinical implications of altitude-induced coagulation changes.