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Adverse results with PMMA fillers
Erick de Melo Carpaneda1, Carlos Augusto Carpaneda
1Instituto de Cirurgia do Lago Ltda., SHIS QI 09 Cj. E Bl. 1, Salas 1 a 6, Lago Sul, Brasília/DF, 71625-009, Brazil. carpaneda@carpaneda.com.br
Aesthetic Plastic Surgery
|March 23, 2012
Summary
Polymethylmethacrylate (PMMA) injections can cause severe acute and chronic complications. Histological analysis reveals capsular contracture around PMMA microspheres, leading to tissue hardening and potential extrusion.
Area of Science:
- Plastic Surgery
- Dermatology
- Histopathology
Background:
- Polymethylmethacrylate (PMMA) is used for body contouring and filling depressions.
- PMMA injections are associated with significant acute and chronic clinical compilations.
- This study investigates the link between PMMA use and the physiopathology of its complications.
Purpose of the Study:
- To correlate the clinical application of PMMA with the physiopathology of acute and late complications.
- To analyze histological findings in patients experiencing side effects from PMMA injections.
Main Methods:
- Histological examination of biopsy samples from patients with PMMA-related complications.
- Samples were obtained from individuals who received PMMA injections at external facilities.
Main Results:
- Histological findings showed tissue encapsulation of individual PMMA microspheres.
- Concentric capsular groups formed around multiple PMMA microspheres.
- These capsules were observed in patients with clinical complications and side effects.
Conclusions:
- PMMA injections can lead to severe acute and chronic complications.
- Acute complications involve vascular compromise.
- Late-phase complications result from capsular contracture around PMMA particles, causing hardening, nodulation, and potential extrusion.
