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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 23, 2026

A New Murine Model of Endovascular Aortic Aneurysm Repair
08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

Aortic atherosclerosis and embolic events.

Muhamed Saric1, Itzhak Kronzon

  • 1Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York, NY 10016, USA. muhamed.saric@nyumc.org

Current Cardiology Reports
|March 23, 2012
PubMed
Summary

Aortic plaques, a sign of atherosclerosis, can cause serious embolisms. Management focuses on general atherosclerosis treatment as specific therapies for aortic embolism are lacking.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Aortic plaques result from atherosclerosis, characterized by lipid accumulation and inflammation in the aorta.
  • These plaques can lead to thromboemboli and atheroemboli, causing diverse clinical manifestations.

Purpose of the Study:

  • To describe the nature of aortic plaques and their embolic potential.
  • To highlight diagnostic modalities and current management strategies for aortic embolism.

Main Methods:

  • Review of the pathophysiology of atherosclerosis and aortic plaque formation.
  • Discussion of clinical consequences of aortic embolism.
  • Emphasis on transesophageal echocardiography for diagnosis.

Main Results:

  • Aortic plaques can generate thromboemboli causing large artery occlusion (e.g., stroke) and atheroemboli causing small artery occlusion (e.g., blue toe syndrome, renal insufficiency).

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Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

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Last Updated: May 23, 2026

A New Murine Model of Endovascular Aortic Aneurysm Repair
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Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
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Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

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  • Transesophageal echocardiography is the standard for visualizing thoracic aortic plaques.

    • Conclusions:

    • Aortic embolism is a significant complication of atherosclerosis with varied clinical presentations.
    • Currently, no specific treatments exist for aortic embolism; management relies on controlling underlying atherosclerosis.