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Nutraceutical preparations in childhood migraine prophylaxis: effects on headache outcomes including disability and

Maria Esposito1, Maria Ruberto, Antonio Pascotto

  • 1Department of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Second University of Naples, Via Sergio Pansini 5, PAD 11, 80131, Naples, Italy.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|March 23, 2012
PubMed

Insights

Ginkgolide B and Griffonia simplicifolia extract show promise for pediatric migraine without aura. Ginkgolide B demonstrated superior effectiveness in reducing headache frequency, duration, and intensity over six months.

Area of Science:

  • Pediatric Neurology
  • Complementary and Alternative Medicine

Background:

  • Migraine is prevalent in school-aged children, yet specific pharmaceutical treatments are limited.
  • Nutraceuticals offer a potential alternative for managing pediatric migraine without aura.

Purpose of the Study:

  • To compare the efficacy of two oral nutraceutical preparations, ginkgolide B and Griffonia simplicifolia extract, in managing migraine without aura in children.
  • To evaluate the impact of these interventions on headache frequency, duration, intensity, and related behavioral aspects.

Main Methods:

  • An open-label, comparative study involving 374 school-aged children diagnosed with migraine without aura.
  • Participants were randomized to receive either ginkgolide B or Griffonia simplicifolia extract orally, twice daily for six months.
  • Headache diaries were maintained, and outcomes were assessed at baseline and after the treatment period.

Main Results:

  • Both ginkgolide B and Griffonia simplicifolia extract significantly reduced headache frequency, duration, and intensity.
  • The ginkgolide B group exhibited significantly greater improvements in all measured outcomes, including PedMIDAS score and behavioral reactions to headache.
  • No significant side effects were reported for either nutraceutical preparation.

Conclusions:

  • Both ginkgolide B and Griffonia simplicifolia extract are promising, safe options for pediatric migraine without aura.
  • Ginkgolide B demonstrated superior medium-term efficacy compared to Griffonia simplicifolia extract in this pediatric population.

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