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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Updated: May 23, 2026

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

Medium to high throughput screening: microfabrication and chip-based technology.

Yuan Wen¹, Xudong Zhang, Shang-Tian Yang

¹William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.

Advances in Experimental Medicine and Biology

|March 23, 2012

Summary

This summary is machine-generated.

Microfluidics and chip-based technologies offer new avenues for medium to high throughput toxicity testing. These innovations enable significant time and cost savings in systemic toxicity studies using in vitro models.

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Area of Science:

Biotechnology
Toxicology
Microfluidics

Background:

Traditional toxicity testing methods are time-consuming and costly.
Advancements in microfabrication and microfluidics present novel opportunities for toxicity assessment.

Purpose of the Study:

To discuss the fundamentals of microfabrication and microfluidics for toxicity testing.
To highlight novel applications of these technologies in toxicity studies.
To emphasize microscale cell and tissue culture models for in vitro systemic toxicity screening.

Main Methods:

Review of microfabrication and microfluidic principles.
Discussion of chip-based technologies for toxicity assessment.
Focus on microscale cell and tissue culture models.

Main Results:

Microfabrication and microfluidics enable new approaches to toxicity testing.
These technologies facilitate medium to high throughput screening.
In vitro microscale models are suitable for systemic toxicity studies.

Conclusions:

Microfluidic and chip-based technologies are transforming toxicity testing.
These innovations lead to significant time and cost efficiencies.
Microscale in vitro models are crucial for advancing systemic toxicity evaluations.