Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 23, 2026

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
09:44

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

A hippocampal cognitive prosthesis: multi-input, multi-output nonlinear modeling and VLSI implementation.

Theodore W Berger1, Dong Song, Rosa H M Chan

  • 1Department of Biomedical Engineering, Center for Neural Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA. berger@bmsr.usc.edu

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
|March 23, 2012
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The 2026 global roadmap for textile-integrated wearable technologies in health.

Physiological measurement·2026
Same author

Integrative PANoptosis-focused omics analysis uncovers GSDMC as a candidate biomarker in breast cancer.

Frontiers in cell and developmental biology·2026
Same author

Baseline patient-reported symptom networks and early risk stratification for six-month symptom burden in newly diagnosed glioma: a prospective cohort study.

Frontiers in public health·2026
Same author

A Roadmap to Navigate the Future of Neural Engineering.

Journal of neural engineering·2026
Same author

<i>In situ</i> biomimetic near-infrared fluorescent protein formed by tumor signature proteins for detecting breast cancer biopsy.

Materials today. Bio·2026
Same author

Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in Aging: A Focus on Spatial Learning and Memory.

Phytotherapy research : PTR·2026

Researchers developed a cognitive prosthesis using a biomimetic model to predict hippocampal activity, restoring memory formation in rats with hippocampal damage. This innovation offers hope for treating memory loss disorders.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Cognitive Science

Background:

  • Hippocampal damage impairs long-term memory formation, affecting cognitive function.
  • The delayed nonmatch-to-sample (DNMS) task in rats is a standard model for studying memory.
  • Restoring memory function is a critical challenge in neuroscience and medicine.

Purpose of the Study:

  • To develop a cognitive prosthesis capable of restoring new long-term memory formation.
  • To create a biomimetic model predicting hippocampal (CA1) output based on presynaptic input.
  • To test the prosthesis's efficacy in restoring DNMS behavior in a rat model.

Main Methods:

  • Utilized a multi-input/multi-output (MIMO) nonlinear model to predict spatio-temporal spike train output of the hippocampus (CA1).

More Related Videos

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
09:59

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus

Published on: October 11, 2017

Related Experiment Videos

Last Updated: May 23, 2026

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
09:44

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
09:59

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus

Published on: October 11, 2017

  • Recorded presynaptic spike trains (e.g., CA3) as input to the MIMO model.
  • Implemented real-time, single-trial predictions and used electrical stimulation to reinstate CA1 activity when function was blocked.

    • Main Results:

    • The MIMO model achieved highly accurate, real-time predictions of CA1-coded memories.
    • Blocking hippocampal CA1 function abolished DNMS behavior, confirming the model's relevance.
    • Restoring CA1 activity via MIMO model predictions successfully reinstated DNMS behavior.

    Conclusions:

    • A biomimetic MIMO model can accurately predict hippocampal memory-related activity.
    • Cognitive prostheses utilizing such models can restore memory function in impaired subjects.
    • A hardware implementation for a cognitive prosthesis is feasible for future applications.