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Skeletal Muscle Gender Dimorphism from Proteomics

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

Ethnic differences in tissue creatine kinase activity: an observational study.

Lizzy M Brewster¹, Carmen M D Coronel, Willem Sluiter

¹Departments of Internal and Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. l.m.brewster@amc.uva.nl

|March 23, 2012

Summary

Black individuals exhibit significantly higher creatine kinase (CK) activity in tissues compared to white individuals. This difference in CK levels may explain observed variations in serum CK and impact tissue energy buffering capacity.

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Published on: October 10, 2019

Area of Science:

Biochemistry and Human Physiology
Population Health Studies
Genetics and Molecular Biology

Background:

Healthy Black individuals show approximately 70% higher serum creatine kinase (CK) levels than white individuals.
Serum CK is believed to originate from normal tissue leakage, suggesting potential differences in tissue CK activity between ethnic groups.

Purpose of the Study:

To investigate whether Black individuals have higher creatine kinase (CK) activity in tissues compared to white individuals.
To explore potential ethnic differences in tissue-specific CK activity.

Main Methods:

Spectrophotometric analysis of CK activity in post-mortem tissues (cerebrum, cerebellum, heart, renal artery, skeletal muscle) from Black and white males.
Mixed linear regression models were used to assess the influence of ethnicity on tissue CK activity, accounting for clustered data within individuals.

Main Results:

Mean tissue CK activity was 76% higher in tissues from Black individuals compared to white individuals (p = 0.002).
Higher CK activity was observed across all studied tissues with high and fluctuating energy demands in the Black population subgroup.

Conclusions:

The study provides evidence for elevated CK activity in multiple tissues of Black individuals, potentially explaining higher serum CK levels.
Findings suggest ethnic variations in CK-dependent ATP buffering capacity, which could be relevant under conditions of high energy demand.