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Updated: May 23, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Update on systemic lupus erythematosus pregnancy
Irene Iozza1, Stefano Cianci, Angela Di Natale
1Santo Bambino Hospital, Department of Microbiological and Gynecological Sciences, University of Catania, Italy.
Journal of Prenatal Medicine
|March 23, 2012
Summary
Women with Systemic Lupus Erythematosus (SLE) face pregnancy risks, but advances improve outcomes. Planning pregnancy during disease quiescence and close monitoring are key for a healthy mother and baby.
Area of Science:
- Rheumatology
- Obstetrics
- Perinatology
Background:
- Systemic Lupus Erythematosus (SLE) presents unique challenges during pregnancy.
- While SLE management has advanced, risks to mother and fetus persist.
- Pregnancy can exacerbate SLE and mimic its symptoms, like preeclampsia.
Purpose of the Study:
- To provide an update on managing pregnancy in women with SLE.
- To inform healthcare providers guiding reproductive decisions for SLE patients.
Main Methods:
- Review of existing literature on SLE and pregnancy.
- Analysis of risks, complications, and management strategies.
Main Results:
- Pregnancy can trigger SLE flares in 50-60% of cases, with severe flares in 10%.
- Maternal mortality is 2-3%; fetal risks include 4.8x higher spontaneous fetal wastage and 6.8x higher premature births.
- Antiphospholipid syndrome/antibodies increase fetal wastage; aspirin/heparin can improve outcomes.
Conclusions:
- Timing pregnancy during SLE quiescence (≥6 months) improves outcomes.
- Close maternal and fetal surveillance (BP, proteinuria, Doppler) is crucial.
- Continued treatment with hydroxychloroquine, low-dose steroids, and azathioprine is often necessary.
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