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Updated: May 23, 2026

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
Published on: June 29, 2011
Protection of cells from nitric oxide-mediated apoptotic death by glutathione C₆₀ derivative
Zhen Hu1, Chunhua Zhang, Peiyi Tang
1School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China.
Abstract:
The influence of the glutathione C₆₀ derivative on the cytotoxicity of a highly reactive free radical NO (nitric oxide) has been investigated. Consistent with its cytoprotective abilities, the derivative scavenges ROS (reactive oxygen species) and RNS (reactive nitrogen species) both in vitro and under cell-free conditions. Moreover, the glutathione C₆₀ derivative protected PC12 cells from the cytotoxic effect of the NO-releasing compound, SNP (sodium nitroprusside). Addition of glutathione C₆₀ derivative alone did not induce apoptosis and necrosis. The results suggest that the glutathione C₆₀ derivative has the potential to prevent NO-mediated cell death without evident toxicity.
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