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Ocular surface changes in eyes with glaucoma filtering blebs
Celso Ricardo Neves Mendes1, Richard Yudi Hida, Niro Kasahara
1Department of Ophthalmology, Santa Casa de São Paulo, São Paulo, Brazil.
Current Eye Research
|March 24, 2012
Summary
Functioning filtering blebs in glaucoma patients can cause dry eye symptoms. Ocular surface changes were observed, but did not strongly correlate with bleb size.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Ocular Surface Disease
Background:
- Glaucoma filtration surgery creates filtering blebs to reduce intraocular pressure.
- The impact of functioning filtering blebs on ocular surface health requires further investigation.
Purpose of the Study:
- To analyze ocular surface changes in patients with functioning filtering blebs.
- To correlate these changes with the size of the filtering bleb.
Main Methods:
- 40 glaucoma patients with functioning blebs and 40 controls underwent vital staining, tear film break-up time (BUT), and Schirmer I-test.
- Statistical analysis included Mann-Whitney U-test and Spearman's rank correlation.
Main Results:
- Eyes with filtering blebs showed significantly higher rose bengal and fluorescein staining compared to controls.
- Tear film break-up time (BUT) was shorter, and Schirmer I-test measurements were greater in the bleb group.
- Ocular staining showed poor correlation with bleb height and extent.
Conclusions:
- Functioning filtering blebs can negatively impact ocular surface stability.
- These blebs may contribute to dry eye-like symptoms in glaucoma patients.
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