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Related Experiment Video

Updated: May 23, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Radiation options for high-grade gliomas.

Benedict Beng Teck Taw1, Alessandra A Gorgulho, Michael T Selch

  • 1Division of Neurosurgery, Department of Surgery, University of Hong Kong, Hong Kong, SAR, China.

Neurosurgery Clinics of North America
|March 24, 2012
PubMed
Summary

High-dose radiotherapy offers better high-grade glioma tumor control but risks side effects. Stereotactic radiosurgery shows mixed results, necessitating further large-scale studies for improved treatment accuracy.

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Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Medical Imaging

Background:

  • Radiotherapy is a standard treatment for high-grade gliomas.
  • High-dose radiation improves tumor control but increases risks of radionecrosis and side effects.

Purpose of the Study:

  • To evaluate the efficacy and outcomes of stereotactic radiosurgery for high-grade gliomas.
  • To explore the role of advanced imaging in improving radiosurgical treatment planning.

Main Methods:

  • Review of published studies on stereotactic radiosurgery for high-grade gliomas.
  • Comparison of stereotactic radiosurgery with conventional conformal radiotherapy.
  • Investigation of new imaging modalities for treatment planning.

Main Results:

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Last Updated: May 23, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
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PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

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  • Large trials indicate no significant survival benefit for stereotactic radiosurgery compared to conventional radiotherapy.
  • Existing studies on stereotactic radiosurgery for gliomas have yielded non-unanimous results.
  • Advanced imaging techniques are under investigation to enhance treatment accuracy.

Conclusions:

  • Further large-scale studies are required to validate the effectiveness of stereotactic radiosurgery and advanced imaging in treating high-grade gliomas.
  • The optimal role of stereotactic radiosurgery in glioma treatment remains under investigation.
  • Balancing tumor control with radiation-related side effects is a critical consideration.