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Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Related Experiment Video

Updated: May 23, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Published on: November 11, 2016

The circadian clock modulates renal sodium handling.

Svetlana Nikolaeva1, Sylvain Pradervand, Gabriel Centeno

  • 1Department of Pharmacology and Toxicology, University of Lausanne, 27 rue du Bugnon, Lausanne, Switzerland.

Journal of the American Society of Nephrology : JASN
|March 24, 2012
PubMed
Summary

The circadian clock regulates blood pressure (BP) by controlling kidney function, particularly sodium excretion. Disruption of the clock gene impairs the 20-hydroxyeicosatetraenoic acid (20-HETE) pathway, affecting BP regulation.

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Area of Science:

  • Physiology
  • Chronobiology
  • Nephrology

Background:

  • The circadian clock influences physiological processes, including blood pressure (BP).
  • Mechanisms linking the circadian clock to renal function and BP control are not fully understood.

Purpose of the Study:

  • To investigate the role of the circadian clock in regulating renal function and BP.
  • To identify specific molecular pathways targeted by the circadian clock in the kidney.

Main Methods:

  • Comparative analysis of circadian rhythms in kidneys of wild-type and clock-deficient mice.
  • Assessment of renal sodium excretion, plasma aldosterone levels, and renal transcriptomes.
  • Pathway analysis focusing on regulators of renal sodium handling and BP.

Main Results:

  • Clock-deficient mice showed disrupted circadian rhythms of renal sodium excretion and plasma aldosterone.
  • Significant alterations were observed in renal circadian transcriptomes related to sodium balance.
  • The 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis pathway was identified as a key target, with reduced 20-HETE levels in clock-deficient mice.
  • A decrease in renal and urinary 20-HETE content correlated with impaired BP regulation.

Conclusions:

  • The circadian clock modulates renal function, impacting BP control.
  • The 20-HETE synthesis pathway is a principal renal target of the circadian clock.
  • Circadian control over renal sodium handling is a significant mechanism by which the clock affects BP.