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Dexamphetamine reduces auditory P3 delta power and phase-locking while increasing gamma power.

Matthew A Albrecht1, Greg Price, Joseph Lee

  • 1Pharmacology & Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, Australia. albrem04@student.uwa.edu.au

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|March 24, 2012
PubMed
Summary

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Dexamphetamine reduced auditory P3 amplitude in healthy individuals by decreasing delta frequency power and phase-locking, mimicking schizophrenia findings. This suggests elevated catecholamine activity may underlie these auditory processing deficits in schizophrenia.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Reduced auditory P3 amplitude is a key finding in schizophrenia.
  • This reduction is linked to decreased power and phase-locking in delta and theta frequencies.
  • Previous research showed auditory P3 reduction in healthy individuals after dexamphetamine administration.

Purpose of the Study:

  • To investigate if dexamphetamine-induced auditory P3 reduction shares power and phase-locking characteristics with schizophrenia.
  • To explore the role of catecholamine activity in auditory P3 alterations.

Main Methods:

  • A double-blinded, placebo-controlled, cross-over study with 44 healthy participants.
  • Administration of dexamphetamine (0.45 mg/kg) or placebo.
  • Auditory odd-ball task with wavelet analysis of delta, theta, alpha, beta, and gamma frequencies around the P3 peak.

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Main Results:

  • Dexamphetamine significantly reduced delta power and phase-locking around the P3 peak.
  • Theta power and phase-locking remained unaffected.
  • A significant increase in gamma power around the P3 peak was observed with dexamphetamine.

Conclusions:

  • Increased catecholamine activity may cause the delta component reductions in auditory P3 observed in schizophrenia.
  • The findings link dexamphetamine's effects on delta and gamma power to potential mechanisms underlying auditory processing deficits in schizophrenia.