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Optimized angle scanning method for array sample detection in surface plasmon resonance biosensor.

Pan Qi1, Ying Li, Jingang Zhong

  • 1Department of Optoelectronic Engineering, Jinan University, Guangzhou 510632, China.

Applied Optics
|March 24, 2012
PubMed
Summary

This study introduces an optimized angle scanning method for surface plasmon resonance biosensors to precisely detect array samples. The technique resolves light spot drifting issues, enabling accurate analysis of multiple samples.

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Area of Science:

  • Biosensing Technologies
  • Optical Metrology
  • Surface Science

Background:

  • Surface plasmon resonance (SPR) biosensors are crucial for label-free biomolecular detection.
  • Accurate detection of array samples in SPR requires precise control of light incidence.
  • Drifting of the light incidence point on samples complicates array detection in prism-coupling modes.

Purpose of the Study:

  • To develop an optimized angle scanning method for array sample detection in SPR biosensors.
  • To address and resolve the issue of light incidence point drifting in planar prism-coupling SPR.
  • To enable accurate and efficient detection of multiple samples arranged in an array.

Main Methods:

  • An optimized angle scanning methodology was designed and implemented.

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  • The method identifies the optimal rotation axis for the prism.
  • Array sample detection is achieved through controlled translation of the prism.

    • Main Results:

    • The proposed method effectively resolves the light incidence point drifting problem.
    • Experimental validation confirms the theoretical analysis of the angle scanning technique.
    • Accurate detection of array samples was demonstrated using the optimized method.

    Conclusions:

    • The optimized angle scanning method enhances the reliability of SPR biosensors for array sample analysis.
    • This technique offers a robust solution for improving precision in SPR-based detection systems.
    • The findings facilitate advancements in high-throughput biomolecular screening using SPR technology.