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Related Experiment Video

Updated: May 23, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Molecular staging individualizing cancer management.

Alex Mejia¹, Stephanie Schulz, Terry Hyslop

¹Department of Pharmacology, Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Journal of Surgical Oncology

|March 24, 2012

Summary

Molecular staging improves prognosis assessment for node-negative colon cancer patients. Detecting occult metastases is crucial for predicting outcomes and guiding chemotherapy in colorectal cancer.

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Last Updated: May 23, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Lymph node status is a key prognostic factor in colorectal cancer.
A significant portion of node-negative patients experience recurrence due to occult metastases.

Purpose of the Study:

To highlight the potential of molecular staging in assessing prognosis for node-negative colon cancer.
To emphasize the need for validating molecular staging for personalized patient management.

Main Methods:

Utilizing specific molecular markers for sensitive detection of occult tumor cells.
Employing advanced detection technologies for molecular staging.

Main Results:

Molecular staging offers a powerful platform for prognosis assessment in node-negative colon cancer.
Occult tumor cells are linked to patient prognosis and chemotherapy response.

Conclusions:

Molecular staging is a promising approach for node-negative colon cancer.
Further validation is needed to integrate molecular staging into clinical decision-making for colorectal cancer treatment.