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Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Clinical Trials: Overview

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Updated: May 23, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Ongoing clinical trials in AKI.

Sarah Faubel¹, Lakhmir S Chawla, Glenn M Chertow

¹Division of Nephrology, University of Colorado and Denver Veterans Administration Medical Center, Denver, Colorado, USA. sarah.faubel@ucdenver.edu

Clinical Journal of the American Society of Nephrology : CJASN

|March 24, 2012

Summary

This summary is machine-generated.

Acute kidney injury (AKI) is a significant public health concern. This review analyzes ongoing clinical trials for AKI prevention and treatment, identifying research gaps and future directions.

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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

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Published on: September 18, 2013

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Published on: September 20, 2019

Area of Science:

Nephrology
Critical Care Medicine
Clinical Trials Research

Background:

Acute kidney injury (AKI) is a prevalent hospital complication with high mortality, morbidity, and significant healthcare costs.
Current therapeutic options for AKI are limited, with no specific treatments to prevent, manage, or mitigate its systemic effects.
Recent advancements include a consensus definition for AKI and the identification of novel biomarkers for early detection.

Purpose of the Study:

To review and analyze ongoing clinical trials for AKI prevention and management registered on clinicaltrials.gov.
To serve as a resource for clinicians and researchers interested in AKI prophylactic and therapeutic strategies.
To identify research needs and suggest future research directions in AKI.

Main Methods:

Systematic review and analysis of clinical trials registered with clinicaltrials.gov.
Focus on trials addressing the prevention or management of AKI.
Identification of research gaps based on the current clinical trials portfolio.

Main Results:

Summary and analysis of current AKI-related clinical trials.
Identification of ongoing research in AKI prevention and treatment.
Discussion of research needs not covered by existing trials.

Conclusions:

There is an urgent need for large, definitive randomized clinical trials to test interventions for AKI.
The review provides insights into current research efforts and highlights areas for future investigation.
Further research is crucial to develop effective strategies for preventing and treating AKI and improving patient outcomes.