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Updated: May 23, 2026
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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Consistent and predictable delivery rates after oocyte vitrification: an observational longitudinal cohort
Laura Rienzi1, Ana Cobo, Alessio Paffoni
1Clinica Valle Giulia, G.EN.E.R.A Centre for Reproductive Medicine, Rome, Italy. rienzi@generaroma.it
Human Reproduction (Oxford, England)
|March 24, 2012
Summary
Oocyte vitrification is an effective method for fertility preservation, offering consistent delivery rates across centers. This technique should be routinely used, with a predictive model aiding patient selection and counseling for improved outcomes.
Area of Science:
- Reproductive Medicine
- Cryobiology
- In Vitro Fertilization
Background:
- Oocyte cryopreservation offers solutions to legal and ethical challenges in infertility treatments.
- It also enables fertility preservation for medical and social reasons.
Purpose of the Study:
- To investigate the efficacy and reproducibility of oocyte cryopreservation outcomes in IVF/ICSI cycles.
- To analyze patient and cycle characteristics influencing delivery rates.
Main Methods:
- Observational longitudinal cohort multicentric study.
- Analysis of oocyte survival, fertilization, embryo development, and delivery rates.
- Logistic regression and recursive partitioning for outcome prediction.
Main Results:
- Oocyte vitrification showed an 84.7% survival rate post-warming.
- Delivery rates were 26.3% per cycle and 29.4% per transfer.
- Female age, number of vitrified oocytes, and day of transfer significantly influenced delivery rates.
Conclusions:
- Oocyte vitrification is an efficient and reliable method with predictable delivery rates.
- Consistent results across centers support routine application for various indications.
- A predictive model is proposed to assist in patient counseling and selection.
