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Related Experiment Video

Updated: May 23, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

[Lung transplantation].

R Lischke1, J Simonek, J Pozniak

  • 1III. Chirurgická klinika 1. LF UK a FN Motol, Praha. robert.lischke@fnmotol.cz

Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
|March 27, 2012
PubMed
Summary
This summary is machine-generated.

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Ex-vivo lung perfusion (EVLP) offers a promising solution to improve donor lung utilization and address challenges in lung transplantation, including organ shortage and graft dysfunction. This technique allows for reassessment and repair of donor lungs, potentially enhancing outcomes for patients with end-stage lung disease.

Area of Science:

  • Pulmonology and Transplant Surgery
  • Organ Preservation and Viability Assessment
  • Infectious Disease in Transplantation

Context:

  • Lung transplantation is a critical therapy for end-stage lung disease but faces limitations.
  • Organ donor shortage, early graft failure, infection, and chronic graft dysfunction hinder widespread application.
  • Bronchiolitis obliterans syndrome remains a significant threat to long-term lung transplant survival.

Purpose:

  • To explore ex-vivo lung perfusion (EVLP) as a novel strategy for donor lung preservation.
  • To highlight the role of EVLP in increasing lung utilization through reassessment, treatment, and repair of donor lungs.
  • To emphasize the critical importance of managing infections, including viral and bacterial pathogens, to prevent complications like bronchiolitis obliterans syndrome.

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

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Last Updated: May 23, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Summary:

  • Ex-vivo lung perfusion (EVLP) maintains donor lungs in physiological conditions, enabling pre-transplant evaluation and intervention.
  • EVLP can potentially increase the pool of viable donor lungs by treating and repairing organs.
  • Managing infections is crucial due to their association with early morbidity, mortality, and chronic graft dysfunction, specifically bronchiolitis obliterans syndrome.

Impact:

  • EVLP may significantly improve donor lung utilization rates.
  • Effective management of infections post-transplantation is vital for reducing morbidity and improving long-term outcomes.
  • The lung transplantation program in the Czech Republic demonstrates comparable results to international centers, performing approximately 20 transplants annually.