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Pathogenesis and treatment of intra-abdominal infection

M A Malangoni1

  • 1Department of Surgery, Metro Health Medical Center, Case Western Reserve University, Cleveland, Ohio 14109.

Surgery, Gynecology & Obstetrics
|January 1, 1990
PubMed

Insights

Intra-abdominal infections are serious and often require drainage and broad-spectrum antibiotics. Newer antibiotic options offer effective treatment with reduced toxicity compared to older drugs.

Area of Science:

  • Infectious Diseases
  • Surgical Gastroenterology

Background:

  • Intra-abdominal infection presents a significant life-threatening risk.
  • Common causes include perforated viscera, trauma, and inflammatory conditions.
  • Management varies from percutaneous drainage for simple abscesses to open surgical drainage for complex cases.

Purpose of the Study:

  • To review the management strategies for intra-abdominal infections.
  • To highlight the importance of appropriate antimicrobial therapy.
  • To discuss the role of newer antibiotics in treatment.

Main Methods:

  • Review of current medical literature on intra-abdominal infections.
  • Analysis of treatment approaches including drainage techniques and antimicrobial selection.
  • Evaluation of antibiotic efficacy and toxicity profiles.

Main Results:

  • Simple abscesses are amenable to image-guided percutaneous drainage.
  • Complex abscesses necessitate open surgical intervention.
  • Polymicrobial infections require broad-spectrum antibiotics covering gram-positive, aerobic, and anaerobic gram-negative bacteria.

Conclusions:

  • Effective management hinges on source control (drainage) and appropriate antimicrobial therapy.
  • Newer antibiotic agents provide effective treatment options for intra-abdominal infections.
  • Modern antibiotics can achieve successful outcomes while mitigating the toxicity associated with older agents like aminoglycosides.

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