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[Lipid peroxidation in different tissues of rats treated with 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine]
Ruijin Li1, Wanqing Li, Jingfang Xie
1Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006, China. lirj@sxu.edu.cn
Objective:
To study the effects of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) (a kind of heterocyclic amines) on lipid peroxidation in the heart, lung, liver and kidney of rats.
Methods:
Rats were divided into a normal control group and three PhIP groups exposed to different doses of PhIP (5, 10 and 15 mg/kg body weight) by gavage. The indexes of lipid peroxidation were measured 24 hours after gavaging.
Results:
In comparison with the control group, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were increased in hearts and lungs while were significantly inhibited in livers of rats in PhIP groups at the doses of 10 and 15 mg/kg body weight (P < 0.05 or P < 0.01). There was no significant change in kidneys. Moreover, malondialdehyde (MDA) levels in the tissues of rats increased with a dose-dependent manner for PhIP exposure.
Conclusion:
PhIP could cause lipid peroxidation in the heart, lung, liver and kidney of rats, and such effects were varied in different organs.