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Ovarian Sertoli-Leydig cell tumor in a 9-month-old infant with special histologic pattern
Hong Shu1, Xiang hong Yang, Ai Feng Gao
1Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China. shuhong0302@hotmail.com
Insights
This report details the youngest infant diagnosed with ovarian Sertoli Leydig cell tumors (SLCTs), primarily composed of Leydig cells. The patient recovered well after surgery, showing no recurrence after 40 months.
Area of Science:
- Pediatric Oncology
- Gynecologic Pathology
Background:
- Sertoli Leydig cell tumors (SLCTs) are rare ovarian neoplasms.
- Infantile presentations of SLCTs are exceptionally uncommon, particularly those with a predominant Leydig cell component.
Observation:
- A 9-month-old infant presented with a left ovarian SLCT.
- Histological examination revealed a predominant Leydig cell pattern, making this the youngest reported case.
- Elevated serum estradiol and alpha-fetoprotein (AFP) levels were noted.
Findings:
- The patient underwent a left oophorectomy.
- No adjuvant therapy was administered post-surgery.
- The patient remained disease-free with no recurrence observed at 40 months post-operation.
Implications:
- This case highlights the possibility of SLCTs in very young infants.
- A predominant Leydig cell pattern in pediatric SLCTs may have specific clinical implications.
- Successful surgical management without adjuvant therapy suggests a favorable prognosis for select pediatric SLCT cases.
Abstract:
A 9-month-old infant with left ovarian Sertoli Leydig cell tumors (SLCTs) was reported and the special histological pattern was that the main components of the tumor were leydig cells. She was the youngest reported case of the tumor. The patient had increased serum estradiol and A-Fetoprofein (AFP) and a left oophorectomy was performed. After surgery, the patient has not received any treatment. So far, the patient has been well and survived without recurrence for 40 months.
