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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Standard guidelines for the chromosome-centric human proteome project.

Young-Ki Paik¹, Gilbert S Omenn, Mathias Uhlen

¹Yonsei Proteome Research Center and Department of Integrated Omics for Biomedical Science, World Class University Program, Yonsei University, Seoul, Korea. paikyk@yonsei.ac.kr

Journal of Proteome Research

|March 27, 2012

Summary

The Chromosome-Centric Human Proteome Project (C-HPP) maps human proteins by chromosome. Established guidelines ensure collaborative efforts for comprehensive human proteome analysis.

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Area of Science:

Proteomics
Genomics
Human Biology

Background:

The international Chromosome-Centric Human Proteome Project (C-HPP) aims to map and annotate all proteins encoded by human genes.
It fosters collaboration among research teams mapping individual chromosomes and investigating genetic mechanisms of colocated genes.

Purpose of the Study:

To organize a collaborative network for protein mapping of human chromosomes.
To promote the development of proteome analysis and integrate findings from molecular omics platforms.
To establish standard guidelines for efficient international research efforts.

Main Methods:

Collaborative network organization among research teams.
Development and implementation of standard guidelines for experimental approaches, data production, quality control, and data transparency.
Integration of findings from molecular omics technologies.

Main Results:

Establishment of the C-HPP consortium with defined guidelines for collaborative research.
Mobilization of resources and collaborative networks for efficient proteome mapping.
Foundation laid for a companion Biology and Disease-Driven HPP (B/D-HPP) initiative.

Conclusions:

The C-HPP guidelines provide a framework for collaborative consensus and efficient management of international proteome research.
Adherence to these guidelines is expected to facilitate a comprehensive analysis of the human proteome.
The project promotes interdisciplinary collaboration and the integration of diverse omics data.