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Effects of soman on calcium influx into rabbit aorta
C H Hsu1, C Y Hu, C P Robinson
1College of Pharmacy, University of Oklahoma, Oklahoma City 73190.
Abstract:
The acute addition of 10 microM soman to rabbit aorta rings did not increase resting 45Ca2+ influx significantly in the absence or presence of 10 microM norepinephrine or 80 mM potassium (P greater than 0.05). However, agonist-induced 45Ca2+ influx into aorta rings from rabbits that received soman daily for 7 days was significantly reduced (P less than 0.05) compared to agonist-induced influx into rings from control rabbits. The resting influx of 45Ca2+ into aorta rings from 7 day soman-treated and control rabbits was not different (P greater than 0.05). The depression by soman of norepinephrine- and K(+)-induced 45Ca2+ influx may be due to adaptive changes resulting from the 7-day administration of soman.