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Updated: May 23, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Pharmacokinetics and disposition of nanomedicine using biodegradable PEG/PCL polymers as drug carriers
YuJun Wang1, MaLing Gou, ChangYang Gong
1State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China.
Abstract:
Micelles assembled from amphiphilic poly(ethylene glycol)/poly(-caprolactone) (PEG/PCL) copolymers are promised as safe and effective drug delivery systems. They offer the potential to achieve high solubility of hydrophobic drugs, long blood circulation time and effective delivery to target organs. These advantages contribute to their application as vehicles of a broad variation of therapeutic compounds. In this review, we discussed the safety of the copolymers, release behavior of PEG/PCL micelles in vitro, and pharmacokinetic profiles referring to the optimized fate in vascular system and targeting biodistribution.
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