Synthesis and biological evaluation of (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine
Jeremy L Clark1, Carey B Clark, J Christian Mason
1Cejera, LLC, Birmingham, Alabama, USA. 01j.clark@gmail.com
Nucleosides, Nucleotides & Nucleic Acids
|March 27, 2012
Abstract:
The novel pyrimidine nucleoside, (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine (1) was synthesized from cytidine in seven steps. The key step in the synthesis was the introduction of the tertiary fluorine at the 3'-position. Compound 1 was evaluated in vitro against several RNA viruses.


