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[Early clinical indicators of pervasive development disorders]
G García-Ron1, F Carratalá, P Andreo-Lillo
1Unidad de Neuropediatría, Hospital Universitario de San Juan de Alicante, San Juan de Alicante, España.
Insights
Early identification of pervasive developmental disorders (PDD) in infants is crucial. Key indicators include delayed speech, lack of eye contact, and increased tantrums, suggesting an early developmental phenotype.
Area of Science:
- Developmental psychology
- Pediatric neurology
- Clinical genetics
Context:
- Pervasive developmental disorders (PDD) are characterized by developmental deficits.
- Early diagnosis and intervention are critical for improving long-term outcomes.
- Recent increases in PDD diagnoses necessitate the study of early, detectable traits.
Purpose:
- To identify easily detectable clinical traits in the first year of life for improved PDD diagnosis.
- To investigate potential early indicators of pervasive developmental disorders in infants.
Summary:
- A study compared 37 PDD patients and 69 controls using somatometric, neurological, and M-CHAT questionnaire data.
- Significant differences in PDD group included higher male-to-female ratio, delayed first disyllabic words, absence of visual contact, lack of response to attention, and increased tantrums.
Impact:
- Detected differences may serve as early warning signs for maturational delay and potential pervasive developmental phenotypes.
- These findings can aid clinicians in identifying infants at risk for PDD.
- Further research can refine these indicators into a diagnostic tool for early intervention.
Introduction:
Pervasive development disorders (PDD) conditions characterised by deficits in many areas of behaviour, such as delay in social interactions, abnormalities in verbal and non-verbal communication, and the presence of the restrictive and repetitive interests. The relevance of early diagnosis is based on the fact that early intervention could have a beneficial effect on the long term outcome. Due to the increase of the PDD diagnosis in the recent years, we aimed to study easily detectable clinical traits during the first year of life, leading to an improvement in the diagnosis.
Patients And Interventions:
A prospective and retrospective study was conducted on 37 PDD patients and 69 healthy controls. Somatometric and neurological examinations were performed and a questionnaire with several variables from the Modified Checklist for Autism in Toddlers (M-CHAT) completed by the parents.
Results:
The male to female ratio (OR: 3.87; 95% CI: 1.23-12.96), delay in the first disyllabic words (PDD=20.1±23 months vs Control=10.8±10.3 months; P<.01), absence of visual contact (OR: 0.05; 95% CI: 0.01-0.29), the lack of response to attention call (OR: 0.12; 95% CI: 0.02-0.67), and the increase in tantrums (OR: 6.37; 95% CI: 2.39-17.34), were significantly higher in the PDD group.
Conclusions:
The differences detected between groups can not been considered as a diagnostic tool of certainty in this time period, however, we believe that they should be considered in the context of maturational delay, as alarm signs in infants and toddlers, as well as suggesting the existence of an early pervasive development phenotype.
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