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Sulfur containing compounds as antioxidants.

P M Dansette1, A Sassi, C Deschamps

  • 1Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, UA 400 CNRS, Université René Descartes, Paris, France.

Advances in Experimental Medicine and Biology
|January 1, 1990
PubMed
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Sulfur-containing antioxidants, like SULFARLEM, show promise as hepatoprotectors and radioprotectors. This study presents preliminary human pharmacokinetic data and demonstrates SULFARLEM

Area of Science:

  • Pharmacology
  • Hepatology
  • Radioprotection

Background:

  • Sulfur-containing compounds are recognized for therapeutic applications as hepatoprotectors and radioprotectors.
  • SULFARLEM, a dithiolthione, has a 40-year history as an anticholestatic drug.
  • Evidence suggests SULFARLEM possesses antioxidant properties.

Purpose of the Study:

  • To evaluate the antioxidant, hepatoprotective, and radioprotective effects of SULFARLEM.
  • To present preliminary human pharmacokinetic data for SULFARLEM.

Main Methods:

  • Pharmacokinetic analysis in human subjects.
  • Assessment of hepatoprotective and radioprotective effects in mouse models.

Main Results:

Related Experiment Videos

  • SULFARLEM demonstrated antioxidant activity.
  • Preliminary human pharmacokinetic data were obtained.
  • Significant hepatoprotective and radioprotective effects were observed in mice.

    • Conclusions:

    • SULFARLEM exhibits promising antioxidant, hepatoprotective, and radioprotective potential.
    • Further investigation into SULFARLEM's therapeutic applications is warranted based on these findings.