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Is it a safe practice to administer oxygen during uncomplicated delivery: a randomized controlled trial?
Tetyana H Nesterenko1, Ceyda Acun, Mohamed A Mohamed
1Department of Neonatology, George Washington University and Children's National Medical Center, 900 23rd Street NW, Washington, DC 20037, United States.
Early Human Development
|March 27, 2012
Summary
Maternal oxygen administration before delivery did not alter umbilical cord markers of oxidative stress. However, infants born to mothers receiving oxygen required more resuscitation in the delivery room.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Biochemistry
Background:
- Newborns exposed to oxygen can experience oxidative stress.
- This stress is associated with changes in superoxide dismutase (SOD) and glutathione (GSSG) concentrations.
- Investigating maternal oxygen administration effects on newborns is crucial.
Purpose of the Study:
- To evaluate the biological and clinical impact of administering oxygen to mothers during delivery.
- To assess changes in oxidative stress markers in maternal and umbilical cord blood.
Main Methods:
- A randomized, double-blinded, controlled trial involving 56 delivering women.
- Comparison between a group receiving 100% oxygen and a room air group before delivery.
- Measurement of SOD and GSSG in maternal and umbilical cord blood.
Main Results:
- No significant differences in maternal or umbilical cord SOD and GSSG levels were observed between groups.
- A higher incidence of delivery room resuscitation was noted in infants of mothers who received oxygen (20% vs. 0%, P=0.03).
- This increased resuscitation need was not attributable to confounding factors like delivery mode or infant sex.
Conclusions:
- Maternal oxygen exposure during delivery does not alter umbilical cord SOD or GSSG levels.
- The increased need for neonatal resuscitation in the oxygen group warrants further investigation into underlying mechanisms.
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Equipment
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