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Rapid Collection of Floral Fragrance Volatiles using a Headspace Volatile Collection Technique for GC-MS Thermal Desorption Sampling
Published on: December 10, 2019
Fragrance material review on cis-jasmone
J Scognamiglio1, L Jones, C S Letizia
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. jscognamiglio@rifm.org
Summary
This review summarizes toxicologic and dermatologic data for cis-jasmone, a fragrance ingredient. Findings support its safe use in fragrances when evaluated with related ketones.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- Cis-jasmone belongs to the fragrance structural group of ketones, specifically cyclopentanones and cyclopentenones.
- This group is characterized by a cyclopentanone or cyclopentenone ring with an alkane or alkene substituent.
Purpose of the Study:
- To present a comprehensive toxicologic and dermatologic review of cis-jasmone as a fragrance ingredient.
- To summarize available data on cis-jasmone's safety profile.
Main Methods:
- Evaluation and summarization of existing toxicology and dermatology literature pertaining to cis-jasmone.
- Inclusion of data on physical properties, acute toxicity, skin and eye irritation, sensitization, phototoxicity, photoallergy, and genotoxicity.
Main Results:
- Compiled data on cis-jasmone's physical properties and toxicological endpoints.
- Detailed findings on skin irritation, eye irritation, sensitization, and genotoxicity were assessed.
Conclusions:
- Cis-jasmone data were evaluated for its role as a fragrance ingredient.
- This review serves as a component of a broader safety assessment for ketones, cyclopentanones, and cyclopentenones in fragrances.
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