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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: May 23, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Subungual melanoma: an important tip.

B H Miranda¹, D N Haughton, F S Fahmy

¹Plastic & Reconstructive Surgery Department, Countess of Chester Hospital NHS Foundation Trust, Countess of Chester Health Park, Liverpool Road, Chester CH2 1UL, UK. DrBMiranda@googlemail.com

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS

|March 27, 2012

Summary

This summary is machine-generated.

Acral lentiginous melanoma (ALM) is a rare melanoma subtype with poor survival, often due to delayed diagnosis. This case highlights the importance of biopsying less pigmented surrounding skin, not just the nail bed, for accurate ALM diagnosis.

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Acral lentiginous melanoma (ALM) is a rare melanoma subtype, accounting for ~1% of all melanomas.
ALM has a disproportionately poor 5-year survival rate (25-51%) compared to other subtypes, often due to diagnostic delays.
Subungual presentation (under the nail) is uncommon, seen in 1-13% of ALM cases.

Observation:

This report details a unique and challenging case of ALM.
Unusually, the neoplastic pathology was identified in the less pigmented fingertip skin.
The deeply pigmented nail bed, germinal, and sterile matrix showed no evidence of malignancy.

Findings:

The diagnosis of acral lentiginous melanoma was confirmed in the surrounding skin, not the nail bed.
This contrasts with typical presentations where the nail matrix is the primary site of ALM.

Implications:

Biopsy of surrounding, less pigmented skin is crucial in suspected ALM cases.
This approach may improve early detection and patient outcomes for this rare melanoma.
Diagnostic protocols for ALM should consider lesions beyond the nail bed itself.