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Fragrance material review on piperonyl acetate
D McGinty1, C S Letizia, A M Api
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
Piperonyl acetate, a fragrance ingredient, was reviewed for toxicologic and dermatologic effects. Available data indicates its safety for use in fragrances when assessed with other aryl alkyl alcohol simple acid esters (AAASAE).
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- Piperonyl acetate belongs to the aryl alkyl alcohol simple acid esters (AAASAE) fragrance group.
- AAASAE are synthesized by esterifying aryl alkyl alcohols with short-chain carboxylic acids.
Purpose of the Study:
- To conduct a toxicologic and dermatologic review of piperonyl acetate.
- To summarize available safety data for this specific fragrance ingredient.
Main Methods:
- Compilation and evaluation of existing toxicology and dermatology studies.
- Analysis of data including physical properties, acute toxicity, irritation, sensitization, toxicokinetics, and genotoxicity.
Main Results:
- Detailed summary of toxicologic and dermatologic data for piperonyl acetate.
- Data covers a range of endpoints relevant to consumer safety.
Conclusions:
- Piperonyl acetate data is part of a larger safety assessment for the AAASAE group.
- Refer to Belsito et al. (2012) for the comprehensive safety assessment of AAASAE, including piperonyl acetate.
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