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Updated: May 23, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
Published on: April 28, 2020
Effect of granulocyte colony-stimulating factor administration on tissue regeneration due to carbon
Durdi Qujeq1, Roya Abassi, Farideh Faeizi
11Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. dqujeq@hotmail.com
Abstract:
The mechanism by which granulocyte colony-stimulating factor (G-CSF) could lead to the protection from liver injury is not well known. Therefore, the resolution of this role needs further basic and clinical experimental investigation. Acute liver injury was induced in rats by single intraperitoneal injection of a 0.50-mL/kg dose of carbon tetrachloride (CCl4 ). Granulocyte colony-stimulating factor or vehicle of 150 µg/kg was given immediately after intoxicating the liver by CCl4 . The animals were divided into four groups of twelve each. Administration of G-CSF caused a decrease in the activity of liver enzymes, aminotransferases, compared with the untreated group.
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