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Maxillary sinus squamous cell carcinoma with concurrent prolonged foreign body impaction.

Young-Ha Kim¹, Jin Hee Cho, Kwang Jae Cho

¹Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.

The Journal of Craniofacial Surgery

|March 27, 2012

Summary

A long-term retained bullet splinter in the maxillary sinus led to squamous cell carcinoma. This case highlights the potential for chronic foreign body reactions to induce cancer, even decades later.

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Area of Science:

Oncology
Pathology
Otorhinolaryngology

Background:

The maxillary sinus is a potential site for malignancy.
Foreign body reactions are known to trigger oncogenesis in various tissues.
Chronic inflammation is a recognized risk factor for cancer development.

Observation:

A case of squamous cell carcinoma (SCC) was identified in the maxillary sinus.
The SCC developed at the site of a bullet splinter retained for approximately 60 years.
The bullet splinter was analyzed and determined to be composed of iron.

Findings:

A rare instance of cancer formation linked to a chronic foreign body in the maxillary sinus.
Demonstrates a latency period of approximately 60 years between foreign body implantation and cancer diagnosis.

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Last Updated: May 23, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Highlights the role of iron as a potential contributing element in foreign body-induced carcinogenesis.

Implications:

Suggests the need for vigilance regarding long-retained foreign bodies in the sinonasal cavity.
Underscores the potential for chronic inflammation from inert materials to lead to malignant transformation.
Provides a unique case study for understanding the pathogenesis of foreign body-associated cancers.