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Serum interleukin-16 levels in patients with nasal polyposis
Kemal Keseroğlu1, Erden Banoğlu, Yusuf Kizil
1Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey.
Objective/Hypothesis:
Several inflammatory and allergic disorders have been reported to correlate with interleukin-16 (IL-16). IL-16 is a highly potent chemotactic and chemoattractant molecule for eosinophils. Nasal polyposis (NP) has an inflammatory basis, and eosinophilia is a common finding in polyp tissue. In this study, we aimed to determine serum IL-16 levels in NP patients.
Study Design:
Prospective controlled study in a tertiary academic hospital.
Methods:
Peripheral blood samples were obtained and used for serologic studies with enzyme-linked immunosorbent assay kits to determine IL-16 levels.
Results:
The study and the control groups consisted of 17 and 10 patients, respectively. Mean serum IL-16 levels were significantly higher in the study group when compared to the control group (447.9 pg/mL vs. 260.2 pg/mL) (P < .001).
Conclusions:
Serum IL-16 levels are significantly elevated in NP patients. This finding may represent identification of a valuable serum biomarker and potential therapeutic target in NP patients.
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