Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Muscle involvement in the scleroderma syndromes.

R A Ringel1, J E Brick, J F Brick

  • 1Department of Neurology, West Virginia University Health Sciences Center, Morgantown 26506.

Archives of Internal Medicine
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The war on cancer: demonstrating the impact of aging upon cancer mortality.

Military medicine·2010
Same author

Medical ethics, logic traps, and game theory: an illustrative tale of brain death.

Journal of medical ethics·2004
Same author

Clinicopathological features of genetically confirmed Danon disease.

Neurology·2002
Same author

Creutzfeldt-Jakob disease and blood transfusions: a meta-analysis of case-control studies.

Military medicine·2002
Same author

Delayed diffuse neurodegeneration after cerebral concussion.

Military medicine·2001
Same author

The latency between traumatic axonal injury and the onset of amyotrophic lateral sclerosis in young adult men.

Military medicine·2001
Same journal

Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

Archives of internal medicine·2017
Same journal

Occult Carbon Monoxide Poisoning-Reply.

Archives of internal medicine·2017
Same journal

Acquired Immune Deficiency Syndrome-Reply.

Archives of internal medicine·2017
Same journal

Heparin Side Effects-Reply.

Archives of internal medicine·2017
Same journal

Humanizing primary care medicine begins with stress.

Archives of internal medicine·2017
Same journal

Legend omitted and number misrepresented.

Archives of internal medicine·2013
See all related articles

Muscle involvement in scleroderma can mimic inflammatory myopathies, presenting as symmetrical proximal weakness. Diagnosis relies on creatine kinase levels, electromyography, and muscle histopathology revealing vasculopathy or polymyositis.

Area of Science:

  • Rheumatology
  • Neurology
  • Pathology

Background:

  • Scleroderma and connective tissue diseases can manifest with muscle involvement.
  • Muscle weakness in these conditions can be indistinguishable from other inflammatory myopathies.

Purpose of the Study:

  • To investigate the characteristics of muscle involvement in patients with scleroderma or related overlap syndromes.
  • To determine the diagnostic utility of creatine kinase, electromyography, and muscle histopathology.

Main Methods:

  • Retrospective analysis of 14 patients with scleroderma or overlap syndromes.
  • Assessment of clinical presentation, creatine kinase levels, electromyography findings, and muscle histopathology.
  • Histopathological examination focused on identifying vasculopathy and polymyositis.

Related Experiment Videos

Main Results:

  • Muscle involvement presented as symmetrical proximal weakness in all patients.
  • Creatine kinase levels and electromyography were effective in demonstrating muscle involvement.
  • Muscle histopathology revealed scleroderma vasculopathy in some patients and polymyositis in others.
  • These findings often occurred independently of specific scleroderma features or overlap syndromes.

Conclusions:

  • Muscle involvement in scleroderma is clinically similar to other inflammatory myopathies.
  • Diagnostic tools like creatine kinase, electromyography, and muscle biopsy are crucial for identification.
  • Scleroderma vasculopathy and polymyositis are key histopathological findings, sometimes occurring independently of specific systemic features.