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High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old
Zhao-Xue Yin1, Xiao-Ming Shi, Virginia B Kraus
1Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Age and Ageing
|March 27, 2012
Summary
High normal plasma triglyceride levels are linked to better cognitive function in Chinese elderly (80+). Lower triglyceride concentrations were not associated with preserved cognitive function in this oldest-old population.
Area of Science:
- Gerontology
- Neuroscience
- Cardiovascular Health
Background:
- Cognitive decline is a major concern in the aging population, particularly among the oldest-old.
- The role of blood lipids and lipoproteins in cognitive function among very elderly individuals requires further investigation.
Purpose of the Study:
- To investigate the association between blood lipids/lipoproteins and cognitive function in Chinese individuals aged 80 and older.
Main Methods:
- Cross-sectional study utilizing multivariate statistical analysis.
- Included 836 subjects aged 80+ from longevity areas in China.
- Assessed plasma lipids (total cholesterol, triglycerides, LDL-C, HDL-C), blood pressure, glucose, demographics, lifestyle, and cognitive status (MMSE).
Main Results:
- Plasma triglyceride was significantly negatively associated with cognitive impairment.
- Higher triglyceride levels showed a significant linear trend with MMSE scores.
- The highest quartile of plasma triglyceride concentration was associated with a reduced odds ratio for cognitive impairment (OR: 0.52).
- No significant associations were found between cognitive impairment and cholesterol levels.
Conclusions:
- High normal plasma triglyceride levels are associated with the preservation of cognitive function in the Chinese oldest-old.
- Lower triglyceride concentrations were not linked to preserved cognitive function in this population.
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