[Myoclonus during a treatment with diclofenac (author's transl)]

Diclofenac is a non steroïdal anti-inflammatory drug. In 1978, the case of a myoclonic encephalopathy appearing three days after starting a treatment with this drug in a patients with renal insufficiency was published. A few months later, we observed a case of myoclonus of the lower limbs in a young man in good general status, without renal insufficiency, after four full months of this treatment. Myoclonus vanished 48 hours after withdrawal of the drug.