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Updated: May 23, 2026
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
Published on: September 22, 2012
Cellular composition of the thymus in Wistar rats in experimental intracerebral hemorrhage
S P Sergeeva1, L M Erofeeva, M R Sapin
1Department of Histology, Cytology, and Embryology, Moscow State University of Medicine and Dentistry, Ministry of Health and Social Development of Russian Federation, Russia. svetlanapalna@mail.ru
Abstract:
The time course of changes in cellular composition of the thymus after experimental intracerebral hemorrhage was studied in rats with various prognostic resistance to emotional stress. Increased migration of T lymphocyte precursors to the subcapsular zone, activation of T lymphocyte differentiation in the thymus, reduced number of mitotic cells, destruction and intensive migration of thymocytes from the thymus were observed. The severity of changes in cell composition in all layers of the thymus after experimental intracerebral hemorrhage was different in rats resistant and predisposed to emotional stress. Predisposition to emotional stress and stress before surgical modeling of intracerebral hemorrhage affected the severity of changes in the thymus. It is shown that autoimmune and adaptation mechanisms, which are closely interrelated, play an important role in the pathogenesis of the intracerebral hemorrhage.
