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Updated: May 23, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
[Pregabalin--a drug with abuse potential?].
1Institut für Rechtsmedizin und Verkehrsmedizin am Universitätsklinikum Heidelberg.
This case report details pregabalin misuse in a drug addict, presenting with delusional ideas. High serum pregabalin levels were detected, highlighting the potential for substance abuse, especially in dependent individuals.
Area of Science:
- Pharmacology
- Clinical Toxicology
Context:
- Pregabalin is approved for epilepsy, neuropathic pain, and anxiety disorders.
- It's investigated for treating substance dependencies like alcohol and benzodiazepines.
- Growing evidence suggests potential for pregabalin abuse, particularly among substance-dependent individuals.
Purpose:
- To report a case of pregabalin misuse associated with delusional ideation.
- To quantify serum pregabalin concentration in a case of misuse.
- To contribute to the understanding of pregabalin's abuse potential.
Summary:
- A case of pregabalin misuse in a drug addict presenting with delusional ideas is described.
- Serum pregabalin concentration was determined using LC/MS/MS, revealing a high level (25 pg/mL).
- The patient experienced paradoxical agitation, anxiety, and abnormal thinking, prompting further investigation into pregabalin's abuse liability.
Impact:
- This case highlights the need for vigilance regarding pregabalin misuse.
- Quantified high serum levels provide crucial data for clinical toxicology.
- Further research is warranted to fully assess the abuse potential of pregabalin.
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