Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial cell dysfunction and postoperative complications in patients with severe mesenteric traction syndrome: A prospective cohort study.

Microvascular research·2026
Same author

Feasibility of 3-dimensional printing coronary arteries to optimize coronary artery bypass graft insertion.

JTCVS techniques·2026
Same author

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules.

Frontiers in immunology·2025
Same author

Explainable machine learning to identify chronic lymphocytic leukemia and medication use based on gut microbiome data.

Microbiology spectrum·2025
Same author

Pro- and Anti-Inflammatory Responses and Clinical Outcomes in Critically Ill Patients With Endotheliopathy: A Cohort Study.

Acta anaesthesiologica Scandinavica·2025
Same author

Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome.

The New England journal of medicine·2025

Related Experiment Video

Updated: May 23, 2026

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

Equally increased hypercoagulability irrespective of using minimized or conventional ECC systems.

Ann S Steinbrüchel1, Pär I Johansson, Sulman Rafiq

  • 1Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Denmark. anra@ruc.dk

Scandinavian Cardiovascular Journal : SCJ
|March 28, 2012
PubMed
Summary

Minimized extracorporeal circulation systems in coronary artery bypass surgery do not appear to protect against postoperative hypercoagulability. Both mini and conventional systems resulted in similar coagulation status and no clinical differences were observed.

More Related Videos

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Related Experiment Videos

Last Updated: May 23, 2026

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Area of Science:

  • Cardiovascular Surgery
  • Hematology
  • Coagulation Science

Background:

  • Minimized extracorporeal circulation (MECC) systems may offer advantages over conventional systems in coronary artery bypass grafting (CABG).
  • Concerns exist regarding MECC's impact on hematological parameters and bleeding post-CABG.
  • The potential for MECC to influence postoperative hypercoagulability requires investigation.

Purpose of the Study:

  • To evaluate the postoperative hypercoagulative status in patients undergoing CABG using MECC versus conventional extracorporeal circulation (CECC).
  • To determine if MECC systems lead to a different hemostatic balance compared to CECC.

Main Methods:

  • Randomized allocation of high-risk patients to either MECC or CECC for CABG.
  • Serial thrombelastographic (TEG) analysis performed preoperatively, and at 1 and 5 days post-surgery.
  • Assessment of hemoglobin levels, platelet counts, and transfusion requirements.

Main Results:

  • Preoperative hypercoagulability was observed in over 50% of patients in both groups, normalizing by postoperative day 1.
  • At day 5, the MECC group showed a trend towards exceeding preoperative clot strength (P=0.03), but no significant intergroup difference was found.
  • Hemoglobin and platelet levels decreased post-surgery, with platelets fully normalizing by day 5; no differences in transfusion needs were noted between groups.

Conclusions:

  • MECC systems do not appear to mitigate the postoperative hypercoagulable state following CABG compared to conventional systems.
  • No clinically significant differences in coagulation status or transfusion requirements were observed between MECC and CECC.
  • Patients undergoing CABG with MECC may not be protected from developing increased postoperative hypercoagulability.