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Cloning and sequencing of human LH/hCG receptor cDNA
T Minegishi1, K Nakamura, Y Takakura
1Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.
Biochemical and Biophysical Research Communications
|November 15, 1990
Abstract:
We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracellular domain which contains six N-linked glycosylation sites. While the protein is 85 and 87% identical overall with the previously cloned rat and porcine LH/hCG receptor respectively, the most highly conserved regions are the putative transmembrane segments (91 and 94% similarity, respectively).