Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Serum Copper-to-Zinc Ratio and Oxidative Stress Are Associated with Anemia in Older Adults with Cardiovascular-Kidney-Metabolic Syndrome.

International journal of molecular sciences·2026

Same author

Virtual reality assessment of cognitive performance in adults with ADHD and problematic internet use: a pilot study.

Frontiers in psychology·2026

Same author

Peripheral nerve conduction in youth with type 1 diabetes: A longitudinal analysis of clinical and glycemic predictors.

Diabetic medicine : a journal of the British Diabetic Association·2026

Same author

Appendiceal Mucinous Neoplasms and Pseudomyxoma Peritonei: Current Classification and the Role of Intraperitoneal Chemotherapy.

Cancers·2026

Same author

Circulating miRNAs in pediatric obesity: a single-center exploratory study of their potential association with renal function.

Frontiers in molecular biosciences·2026

Same author

Physicochemical Stability of Dentin-Derived Biomaterials During Long-Term Storage.

Journal of functional biomaterials·2026

Search research articles

Related Experiment Video

Updated: May 23, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Circulating progenitor cells and the elderly: a seven-year observational study.

Giuseppe Mandraffino¹, Maria A Sardo, Stefania Riggio

¹Department of Internal Medicine and Medical Therapy, University of Messina, Messina, Italy.

Experimental Gerontology

|March 28, 2012

Summary

Higher numbers of CD34+ progenitor cells in octogenarians predict longevity and survival. These cells, involved in cardiovascular health, may serve as a key biomarker for aging well.

More Related Videos

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Published on: September 14, 2015

Related Experiment Videos

Last Updated: May 23, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Published on: September 14, 2015

Area of Science:

Gerontology
Cardiovascular Medicine
Stem Cell Biology

Background:

Cardiovascular diseases are a primary cause of mortality in the elderly.
Cardiovascular progenitor cells, like CD34+ cells, are implicated in mitigating atherosclerosis.
Understanding predictors of longevity in centenarians is crucial for public health.

Purpose of the Study:

To investigate if the number of CD34+ progenitor cells predicts longevity in octogenarians.
To examine the association between CD34+ cell antioxidant enzyme expression and mortality.
To evaluate the predictive power of CD34+ cells versus traditional cardiovascular risk factors in the elderly.

Main Methods:

Longitudinal observation of 100 octogenarians over seven years.
Quantification of baseline CD34+ cell counts.
Assessment of CD34+ cell expression of manganese superoxide dismutase (Mn-SOD), catalase (CAT), and glutathione peroxidase type-1 (GPx-1).

Main Results:

Higher baseline CD34+ cell counts were associated with increased longevity and survival.
Traditional cardiovascular risk factors (hypertension, smoking, hypercholesterolemia) lost predictive power in this cohort.
A significant link was found between the redox system of CD34+ cells and mortality.
HDL-C plasma levels also showed reduced predictive capacity.

Conclusions:

CD34+ progenitor cell number is a significant predictor of longevity in the elderly.
CD34+ cells may represent a novel biomarker for healthy aging and survival.
The antioxidant capacity of CD34+ cells is linked to mortality risk in very old individuals.