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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Published on: May 10, 2024

Eosinophils and disease pathogenesis.

Praveen Akuthota1, Peter F Weller

  • 1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Seminars in Hematology
|March 28, 2012
PubMed
Summary
This summary is machine-generated.

Eosinophils, key innate immune cells, are involved in various diseases, including allergic inflammation and tissue damage. Understanding their biology is crucial for future disease treatment strategies.

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Eosinophils are granulocytic innate immune cells.
  • Their presence is notable in various disease states, including eosinophilic hyperproliferative and infiltrative processes.
  • They are also associated with maladaptive T helper 2 (Th2) inflammation.

Purpose of the Study:

  • To review the role of eosinophils in disease pathogenesis.
  • To consider relevant eosinophil biology.
  • To detail eosinophilic disease patterns and mechanisms of tissue infiltration.

Main Methods:

  • Literature review of eosinophil biology and disease association.
  • Analysis of mechanisms underlying eosinophil-mediated fibrosis and hypercoagulability.
  • Examination of eosinophils' role in allergic inflammation.

Main Results:

  • Eosinophils contribute to disease pathogenesis through various mechanisms.
  • Specific patterns of eosinophilic tissue infiltration are observed in different conditions.
  • Eosinophils play a significant role in allergic inflammation and may promote fibrosis and hypercoagulability.

Conclusions:

  • Eosinophils are unique immune cells with a broad spectrum of disease associations.
  • Further research into eosinophil function promises new insights into disease pathogenesis.
  • Understanding eosinophil roles is vital for developing targeted therapeutic strategies.