Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

Development of the Heart

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nox1/4 inhibitor Setanaxib treatment ameliorates cardiac function in mouse models of Duchenne Muscular Dystrophy.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

Impact of microRNAs and long noncoding RNAs in skeletal and cardiac muscles.

Current opinion in physiology·2026

Same author

Phosphoproteomics reveals essential regulatory roles of phosphorylation in marine oligotrophic bacteria.

Marine life science & technology·2026

Same author

In-depth exploration into the multifaceted regulatory mechanisms of carotenoid metabolism in microalgae.

Bioresource technology·2026

Same author

DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development.

Genes & development·2026

Same author

PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy.

Nature cardiovascular research·2026

Search research articles

Related Experiment Video

Updated: May 23, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNAs in heart development.

Ramón A Espinoza-Lewis¹, Da-Zhi Wang

¹Cardiovascular Research Division, Department of Cardiology, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

Current Topics in Developmental Biology

|March 28, 2012

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression and are vital for heart development and function. Aberrant miRNA expression can lead to cardiac dysfunction and disease.

More Related Videos

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Related Experiment Videos

Last Updated: May 23, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Area of Science:

Molecular Biology
Genetics
Cardiology

Background:

MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression post-transcriptionally.
They are involved in crucial cellular processes like proliferation, differentiation, and apoptosis.
miRNAs are expressed in the heart throughout development and in adulthood.

Purpose of the Study:

To summarize the history, biogenesis, and processing of miRNAs.
To elucidate the function of miRNAs in cardiac development, remodeling, and disease.

Main Methods:

Literature review and synthesis of existing research on miRNAs in cardiac biology.

Main Results:

miRNAs regulate gene expression by mRNA degradation or translation inhibition.
Dysregulation or deletion of miRNAs is linked to abnormal cardiac development and function.
Specific miRNAs play roles in embryonic, postnatal, and adult heart physiology.

Conclusions:

miRNAs are critical regulators of cardiac development and homeostasis.
Understanding miRNA function is essential for addressing cardiac diseases.