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Preformulation studies on suppositories by thermal methods
F Giordano1, A La Manna, G P Bettinetti
1Dipartimento di Chimica Farmaceutica, Università di Pavia, Italia.
Bollettino Chimico Farmaceutico
|April 1, 1990
Summary
Differential scanning calorimetry (DSC) revealed interactions between trimethoprim and sulfamethoxypyridazine in fat-based suppositories. These interactions, influenced by the fat base, affect thermal properties and stability over time.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Suppositories are a common dosage form for drug delivery.
- Understanding drug-base interactions is crucial for formulation stability.
Purpose of the Study:
- To investigate the interaction between trimethoprim and sulfamethoxypyridazine in fat-based suppository formulations.
- To evaluate the impact of these interactions on the thermal behavior and stability of suppositories.
Main Methods:
- Differential Scanning Calorimetry (DSC) was employed to analyze thermal behavior.
- Suppositories formulated with Suppocire, Novata, and Witepsol fat bases were studied.
- Liquefaction time and dropping temperature were measured for control.
Main Results:
- The thermal behavior of suppositories was significantly influenced by the chosen fat base.
- Interactions between trimethoprim and sulfamethoxypyridazine were detected and affected thermal properties.
- Storage time impacted the thermal characteristics of the formulations.
Conclusions:
- DSC is a valuable tool for characterizing drug-excipient interactions in suppository formulations.
- Fat base selection and drug-drug interactions are critical factors for suppository stability and performance.