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Related Experiment Videos

Preformulation studies on suppositories by thermal methods.

F Giordano1, A La Manna, G P Bettinetti

  • 1Dipartimento di Chimica Farmaceutica, Università di Pavia, Italia.

Bollettino Chimico Farmaceutico
|April 1, 1990
PubMed
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Differential scanning calorimetry (DSC) revealed interactions between trimethoprim and sulfamethoxypyridazine in fat-based suppositories. These interactions, influenced by the fat base, affect thermal properties and stability over time.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Suppositories are a common dosage form for drug delivery.
  • Understanding drug-base interactions is crucial for formulation stability.

Purpose of the Study:

  • To investigate the interaction between trimethoprim and sulfamethoxypyridazine in fat-based suppository formulations.
  • To evaluate the impact of these interactions on the thermal behavior and stability of suppositories.

Main Methods:

  • Differential Scanning Calorimetry (DSC) was employed to analyze thermal behavior.
  • Suppositories formulated with Suppocire, Novata, and Witepsol fat bases were studied.
  • Liquefaction time and dropping temperature were measured for control.

Main Results:

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  • The thermal behavior of suppositories was significantly influenced by the chosen fat base.
  • Interactions between trimethoprim and sulfamethoxypyridazine were detected and affected thermal properties.
  • Storage time impacted the thermal characteristics of the formulations.

Conclusions:

  • DSC is a valuable tool for characterizing drug-excipient interactions in suppository formulations.
  • Fat base selection and drug-drug interactions are critical factors for suppository stability and performance.