Related Experiment Videos
Coronary myogenic responses to abrupt changes in aortic blood pressure in anaesthetized dogs
M Dambrosio1, D Gattullo, R J Linden
1Istituto di Anestesiologia e Rianimazione, Università di Bari, Italy.
Experimental Physiology
|September 1, 1990
Abstract:
A transient increase in coronary transmural pressure was produced in anaesthetized dogs by occlusion of the descending thoracic aorta. Aortic blood pressure (ABP), left ventricular pressure and coronary flow were measured; coronary vascular resistance (CVR) was calculated. Results were similar in innervated and denervated hearts. Occlusion for 10 and 20 s resulted in no change in CVR for 15 s, followed by a metabolic dilatation attributable to enhanced oxygen demand; after release the fall in ABP resulted in an immediate increase in CVR, caused by vascular elastic recoil, followed by hyperaemia.