Related Experiment Video
Updated: May 23, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance:
Truc T Tran1, Siraya Jaijakul, Cole T Lewis
1University of Houston College of Pharmacy, Department of Internal Medicine, Division of Infectious Diseases, Houston, Texas, USA. Truc.T.Tran@uth.tmc.edu
Abstract:
We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of ≤ 0.094 μg/ml) and high-level resistance to daptomycin (MIC of ≥ 256 μg/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.
Related Concept Videos
Endocarditis III: Medical Management
Endocarditis I: Introduction
Endocarditis IV: Nursing Management
Endocarditis II: Clinical Features of Infective Endocarditis
Diphtheria
Cardiomyopathy II: Dilated Cardiomyopathy