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Determinants of nerve cell patterns during development: a review.

A M Goffinet1

  • 1Department of Physiology, FUNDP Medical School, Namur, Belgium.

European Journal of Morphology
|January 1, 1990
PubMed
Summary

Neural cell pattern formation relies on neuron stabilization post-migration, not just maturation. The reeler gene mutation disrupts this stabilization, impacting brain architecture and highlighting the role of cell-cell interactions in development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Neural cell pattern formation is crucial for central nervous system development.
  • The reeler mutant mouse exhibits significant architectonic anomalies in brain structures.

Purpose of the Study:

  • To define mechanisms controlling neural cell pattern formation in the developing central nervous system.
  • To investigate the role of the reeler mutation in brain embryonic development and cell positioning.

Main Methods:

  • Comparative studies of embryonic brain development in normal and reeler mutant mice.
  • Analysis of neuronal migration, axonal growth, differentiation, and synaptogenesis.

Main Results:

  • Reeler mutation causes less regular early cell patterns, despite normal neuron generation, migration, and axonal growth.

Related Experiment Videos

  • Brain architectonics depend on stabilization of early neurons post-migration, influenced by the reeler gene.
  • Cell-cell interactions (homophilic and heterophilic) are implicated in neural pattern stabilization.

    • Conclusions:

    • The reeler gene is necessary for normal neural cell pattern stabilization.
    • Cell-cell interactions are critical for organizing nerve cell patterns during brain development.
    • A genetic approach is valuable for understanding brain development and related pathologies.